Exo-PDRN Prismatic+

NEW
A white pump bottle of Medik8 EXO-PDRN Prismatic+ Youthful Vitality Serum rests on a white background, surrounded by a clear, glossy smear of the serum texture.
Before and after comparison of a person's forehead and eye area, with a dotted circle highlighting a visible reduction in forehead wrinkles. Below, large text states that 100% of participants noticed a visible reduction in wrinkles in 14 days.
A graphic titled ‘Boost Natural Rejuvenation by over 50% vs Control,’ showing two images comparison of the skin’s dermis and epidermis, pointing to skin cell rejuvenation and increased skin cell rejuvenation with Exo-PDRN Prismatic+. *Proven via ex vivo study measuring Ki67 protein marker foor cell proliferation vs. untreated control after 24 hours
Before and after comparison of a person's under-eye and cheek area, with a dotted circle highlighting improved skin texture. Below, text states it is clinically proven that skin appears visibly smoother and softer by 43% in 7 days.
A portrait of Dr. Ewoma Ukeleghe, wearing a Medik8 lab coat, with the title "AMBASSADRICE MONDIALE MEDIK8". A quote reads: "Exo-PDRN Prismatic+ uses a next-generation vegan PDRN, designed with a unique prismatic structure that allows the PDRN to be absorbed by the skin even when applied topically."
Before and after comparison of a person's outer eye area, with a dotted circle highlighting a visible reduction in crow's feet wrinkles. Below, large text states "7 days" to reveal healthier, radiant, and luminous-looking skin.
A graphic comparing skin penetration levels of different PDRN types using heatmap scans. The title states Prismatic PDRN represents 2x greater skin absorption than traditional PDRN, with 60% deeper penetration. The heatmap for "PDRN PRISMATIQUE" shows significantly more red and orange (high detection) reaching deeper into the skin compared to the "PDRN DE ROSE" and "PDRN DE SAUMON" scans.
Close-up of a smiling woman touching her cheek where a dab of clear serum is applied. Text on the right reads (For complete results).
Scientific comparison of skin cell rejuvenation with control and exo pdrn prismatic+, showing text about natural rejuvenation boost by 50%.
Two Medik8 serums are compared side-by-side against a background with hexagonal patterns. On the left, the white EXO-PDRN Prismatic+ bottle is shown for morning and night use to achieve overall and visible skin rejuvenation. On the right, the black Liquid Peptides Advanced MP bottle is shown for morning and night use to visibly reduce deep wrinkles.
Graphic highlighting key components of Medik8 Exo-PDRN Prismatic+ including prismatic PDRN, triple exosome complex, growth factor MiniProtein and ATP precursor.
A morning and night routine application guide displays Medik8 products on a light grey background with subtle hexagonal shapes. The EXO-PDRN Prismatic+ bottle is highlighted as the "CIBLE" (Target) step in both routines, used after cleansing. In the morning, it is followed by Vitamin C and Sunscreen. At night, it is followed by another Target serum (Liquid Peptides) and a Moisturiser.
Vegan prismatic PDRN design on a light background
A white pump bottle of Medik8 EXO-PDRN Prismatic+ Youthful Vitality Serum rests on a white background, surrounded by a clear, glossy smear of the serum texture.
Before and after comparison of a person's forehead and eye area, with a dotted circle highlighting a visible reduction in forehead wrinkles. Below, large text states that 100% of participants noticed a visible reduction in wrinkles in 14 days.
A graphic titled ‘Boost Natural Rejuvenation by over 50% vs Control,’ showing two images comparison of the skin’s dermis and epidermis, pointing to skin cell rejuvenation and increased skin cell rejuvenation with Exo-PDRN Prismatic+. *Proven via ex vivo study measuring Ki67 protein marker foor cell proliferation vs. untreated control after 24 hours
Before and after comparison of a person's under-eye and cheek area, with a dotted circle highlighting improved skin texture. Below, text states it is clinically proven that skin appears visibly smoother and softer by 43% in 7 days.
A portrait of Dr. Ewoma Ukeleghe, wearing a Medik8 lab coat, with the title "AMBASSADRICE MONDIALE MEDIK8". A quote reads: "Exo-PDRN Prismatic+ uses a next-generation vegan PDRN, designed with a unique prismatic structure that allows the PDRN to be absorbed by the skin even when applied topically."
Before and after comparison of a person's outer eye area, with a dotted circle highlighting a visible reduction in crow's feet wrinkles. Below, large text states "7 days" to reveal healthier, radiant, and luminous-looking skin.
A graphic comparing skin penetration levels of different PDRN types using heatmap scans. The title states Prismatic PDRN represents 2x greater skin absorption than traditional PDRN, with 60% deeper penetration. The heatmap for "PDRN PRISMATIQUE" shows significantly more red and orange (high detection) reaching deeper into the skin compared to the "PDRN DE ROSE" and "PDRN DE SAUMON" scans.
Close-up of a smiling woman touching her cheek where a dab of clear serum is applied. Text on the right reads (For complete results).
Scientific comparison of skin cell rejuvenation with control and exo pdrn prismatic+, showing text about natural rejuvenation boost by 50%.
Two Medik8 serums are compared side-by-side against a background with hexagonal patterns. On the left, the white EXO-PDRN Prismatic+ bottle is shown for morning and night use to achieve overall and visible skin rejuvenation. On the right, the black Liquid Peptides Advanced MP bottle is shown for morning and night use to visibly reduce deep wrinkles.
Graphic highlighting key components of Medik8 Exo-PDRN Prismatic+ including prismatic PDRN, triple exosome complex, growth factor MiniProtein and ATP precursor.
A morning and night routine application guide displays Medik8 products on a light grey background with subtle hexagonal shapes. The EXO-PDRN Prismatic+ bottle is highlighted as the "CIBLE" (Target) step in both routines, used after cleansing. In the morning, it is followed by Vitamin C and Sunscreen. At night, it is followed by another Target serum (Liquid Peptides) and a Moisturiser.
Vegan prismatic PDRN design on a light background
1 / 13
Dullness

Exo-PDRN Prismatic+

  • Rejuvenate
  • |
  • Plump
  • |
  • Illuminate
Youthful Vitality Serum with Prismatic PDRN & Triple Exosome Complex

Boost skin’s natural rejuvenation by +50%[1] with Exo-PDRN Prismatic+, a next-generation PDRN serum rooted in real skin biology. Designed to support the skin’s key natural pathways, helping to restore visible vitality, refine tone and texture, boost luminosity and support calm, resilient-looking skin.

Central to the formula is our Rejuvenation Blueprint, built to address the 3 Rs of Rejuvenation: Recover, Restore and Recharge. This complete skin system delivers a multi-dimensional approach to visible vitality.

Prismatic PDRN helps provide essential building blocks to support and aid in optimal skin recovery and calm visible redness. A highly concentrated triple exosome complex, featuring up to 151 billion exosomes per bottle, and our breakthrough GF MiniProteinTM visibly restores by supporting skin’s natural signalling processes that facilitate skin resilience and reinforce the skin barrier.  An ATP Precursor helps recharge the skin’s natural processes involved in visible rejuvenation, for a smoother, more revitalised complexion.

Please Note: Product packaging shown may be different to the product received due to regional variations
(30ml)
Earn points
Reward Points

Earn 1 point for every $1 spent with our rewards program, Me&Medik8. Simply create an account to join. Collect points every time you shop and redeem them for rewards, including money off future purchases.

You can also enjoy lots of exclusive benefits from secret promotions, free shipping and a gift on your birthday.

Join Medik8 Loyalty to earn points when you shop this product. Sign up now

Reasons to shop Medik8

Free Australia Delivery over $150
15% off your first order
"No questions asked" easy 30 day returns
Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost," while a geometric graphic in the corner reads "Growth Factor MP™ & NAD+ Longevity Booster."
Advanced Pro-Collagen+ Peptide Cream
  • Firm
  • |
  • Hydrate
  • |
  • Lift
 Rejuvenating Anti-Wrinkle Moisturiser With Growth Factor MiniProteinTM & NAD+ Longevity Booster
Select a Size
Key Benefits
Visible Skin Rejuvenation

Scientifically proven to boost the skin’s natural rejuvenation by over 50%.[1] 

Restored Vitality & Luminosity

Clinically proven to improve the look of skin luminosity and vitality in 7 days.[2]

Optimal Skin Recovery Support

Designed to support the skin’s natural recovery processes, making it ideal for daily use and alongside professional treatments.

Visibly Calm, Resilient-Looking Skin

Clinically proven to improve skin barrier function in 7 days.[2]

Refined Tone & Texture

Supports visibly smoother skin with improved tone and texture.

Proven Results
Before
After
Before
After
+50% boost in natural skin rejuvenation[1]
7 days to improved skin barrier function[2]
7 days to improved skin luminosity[2]
7 days to visibly improved skin volume[2]
7 days to improved skin tone[2]
14 days to visibly improved wrinkles[2]
14 days to improved firmness[2]
100% agree this is the perfect post-procedure partner for their in-clinic PDRN treatment[3]
98% agree the results continue to get better with time[3]
[1] Proven via ex vivo study measuring Ki67 protein marker for cell proliferation vs. untreated control after 24 hours.

[2] Proven via independent clinical study on Exo-PDRN Prismatic+ on 60 volunteers over 1 week.
[3] Proven via independent consumer study conducted over 4 weeks on 52 participants who had received injectable polynucleotide treatments within a week of the study.
[4] Proven via in vitro skin penetration study versus salmon and rose PDRN benchmarks.
How to Use

First-time use

If you're new to Exo-PDRN Primastic+, we recommend a patch test at least 24 hours before first use. Learn how to patch test here.

How To Use

After cleansing in the morning and evening, apply 1-2 pumps of Exo-PDRN Prismatic+ evenly across the face, neck & décolletage. Use light upward strokes and allow to fully absorb.

Guide to Layering
Step 2: Target
A white pump bottle of Medik8 EXO-PDRN Prismatic+ Youthful Vitality Serum rests on a white background, surrounded by a clear, glossy smear of the serum texture.
Morning
Evening
Exo-PDRN Prismatic+
(30ml)
Step 1: Cleanse
Medik8 Surface Radiance Cleanse tube displayed on a clean white background with a large, translucent gel texture smear. Text identifies it as a Resurfacing AHA/BHA Mangosteen Cleansing Gel in a 150mL size.
Morning
Evening
Surface Radiance Cleanse™
Select a Size
Step 2: Brighten
Medik8 C-Tetra Advanced bottle displayed on a clean white background with translucent serum droplets, highlighting its lightweight gel-serum texture.
Morning
C-Tetra® Advanced
(0)
Step 4: Renew
Crystal Retinal® Ceramide Eye
Evening
Crystal Retinal® Ceramide Eye
Select a Size
Step 5: Moisturise
Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights
Morning
Evening
Advanced Pro-Collagen+ Peptide Cream
Select a Size
Key Ingredients
ATP Precursor

An energy-carrying molecule that helps optimise the natural processes involved in visible skin rejuvenation.

Prismatic PDRN

A pioneering form of vegan PDRN with a stable tetrahedral structure for 100% better skin absorption than traditional PDRN.[4] Composed of DNA particles that penetrate 61% deeper than traditional PDRN[4] to support skin recovery, help soothe visible irritation and reveal smoother, more youthful-looking skin.

Triple Exosome Complex

Designed to support natural skin signalling processes, resilience and recovery, helping to strengthen the skin barrier and promote a healthier, more radiant-looking complexion.

GF MiniProteinTM

Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels.

Triple Exosome Complex

Designed to support natural skin signalling processes, resilience and recovery, helping to strengthen the skin barrier and promote a healthier, more radiant-looking complexion.

GF MiniProteinTM

Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels.

Full List of Ingredients
Exo-PDRN Prismatic+
Youthful Vitality Serum with Prismatic PDRN & Triple Exosome Complex

Aqua (Water), Glycerin, Niacinamide, Lactobacillus Ferment, Centella Asiatica Leaf Extract, Lactobacillus Extracellular Vesicles, DNA, Punica Granatum Extract, Laminaria Digitata Extract, Oligopeptide-1, Disodium Adenosine Triphosphate, Sodium Hyaluronate, Lysine HCl, Proline, Histidine HCl, Arginine, Threonine, Serine, Valine, Alanine, Panthenol, Glutamic Acid, Leucine, Glycine, Taurine, Allantoin, Isoleucine, Phenylalanine, Polyacrylate Crosspolymer-6, Magnesium Aspartate, Butylene Glycol, Citric Acid, Calcium Pantothenate, Ethylhexylglycerin, 1,2-Hexanediol, Pentylene Glycol, Benzyl Alcohol, Caprylyl Glycol, Dehydroacetic Acid, Phenoxyethanol, Sodium Citrate

*Although we try our best to ensure this list of ingredients is accurate there may be product upgrades from time to time, or slight variants between different regions based on local laws, meaning the only definitive ingredient list is that which is printed on the product packaging.
  • Clinically proven
  • Fragrance-free
  • Dermatologically tested
  • Proven gentle formula
  • Certified by the vegan society
Experts Recommended

"Exo-PDRN Prismatic+ reflects our belief that visible rejuvenation comes from supporting the skin’s inherent biology. We engineered a formula that works with the natural processes skin relies on to recover and function at its best. By addressing Recover, Restore and Recharge together, we help create the optimal conditions for skin to look healthier and visibly rejuvenated."

DANIEL ISAACS
Chief Product Officer & Founding Partner of Medik8
A circular headshot portrait of a man with light brown hair and green eyes, smiling neutrally. He is wearing a white lab coat with 'Medik8' embroidered on the pocket and a black button-up shirt. The background is white.

Complete Your Regime

Reviews

Frequently Asked Questions

Can I use Exo-PDRN Prismatic+ with C-Tetra Advanced?

Absolutely. Exo-PDRN Prismatic+ and C-Tetra Advanced make an ideal duo to help improve the skin’s natural recovery mechanisms. Use C-Tetra Advanced to defend against premature skin ageing and achieve accelerated visible skin brightening, and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery.

Can I use Exo-PDRN Prismatic+ with Liquid Peptides Advanced MP?

Absolutely. Exo-PDRN Prismatic+ and Liquid Peptides Advanced MP make an ideal age-defying duo. Use Liquid Peptides Advanced MP to target expression lines and build visible wrinkle reduction and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery.

Why are you not using spicules like other exosome serums on the market?

Spicules work by creating micro-channels through controlled micro-trauma. We chose not to include spicules as that can be unnecessarily harsh on post-treatment skin.

Instead, Exo-PDRN Prismatic+ uses a carefully engineered combination of advanced ingredients to deliver results in a gentler, more comfortable way, without placing unnecessary stress on the skin.

Is Exo-PDRN Prismatic+ suitable for oily skin?

Yes. Exo-PDRN Prismatic+ is oil-free and suitable for oily skin types. It delivers an instant healthy glow without leaving skin looking shiny.

Is it suitable for sensitive skin?

Yes. Exo-PDRN Prismatic+ is designed to be gentle and suitable for sensitive skin.

Has it been tested on all skin types?

Yes. Exo-PDRN Prismatic+ has been tested on all skin types.

Is Exo-PDRN Prismatic+ suitable for dry skin?

Yes. The formula contains hydrating and soothing ingredients, making it suitable for dry skin. Due to its water-light texture, we recommend following with a moisturiser for optimal comfort and results.

Can I use Exo-PDRN Prismatic+ with exfoliating acids?

Yes. Exo-PDRN Prismatic+ can be applied after exfoliating acids. We recommend following with a moisturiser to help support the skin barrier and minimise the risk of any dryness.

Can I use it with sunscreen?

Absolutely. Its lightweight texture is designed to layer well under sunscreen, making it suitable for both morning and evening routines.

Can I use it with makeup?

Yes. Exo-PDRN Prismatic+ has been tested to layer seamlessly under makeup, making it ideal for everyday use.

Does the Exo-PDRN Prismatic+ contain fragrance?

No. Exo-PDRN Prismatic+ is fragrance-free, making it suitable for even the most sensitive skin types.

Can I use Exo-PDRN Prismatic+ with exfoliating acids?

Yes. Exo-PDRN Prismatic+ can be applied after exfoliating acids. We recommend following with a moisturiser to help support the skin barrier and minimise the risk of any dryness.

Can I use it with sunscreen?

Absolutely. Its lightweight texture is designed to layer well under sunscreen, making it suitable for both morning and evening routines.

Can I use it with makeup?

Yes. Exo-PDRN Prismatic+ has been tested to layer seamlessly under makeup, making it ideal for everyday use.

Is it suitable for sensitive skin?

Yes. Exo-PDRN Prismatic+ is designed to be gentle and suitable for sensitive skin.

Has it been tested on all skin types?

Yes. Exo-PDRN Prismatic+ has been tested on all skin types.

Does the Exo-PDRN Prismatic+ contain fragrance?

No. Exo-PDRN Prismatic+ is fragrance-free, making it suitable for even the most sensitive skin types.
Exo-PDRN Prismatic+
(30ml)
(30ml)